Drugs being investigated for treatment vs. Covid 19

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Rizal Philippines
April 18, 2020

From Livescience - drugs vs Coronavirus being investigated

There are quite a number:

1.  EIDD 2081 published in Science Transnational Medicine can be an oral medicine just  like Tamiflu. Unlike remdesivir (given by injection) which kills virus entirely, EIDD introduces mutation into the RNA of the virus so that it stops reproducing itself.  The drug has been licensed by Ridgeback Biotherapeutics Florida based, and has obtained license  for clinical trials

2.  Japan Anti Flu Drug -   Avigan (Favipiravir)  was an anti flu drug made by FujiFilm Pharmaceutical and works with mild to moderate  cases and was shown to be effective in 340 cases in Wuhan China.  However, of late, because of disruption in supply chain, Japan would not be able to cope up with the demand.

The drug prevents certain virus from replicating  and improves lung condition (Dr. Sultan reports that the action of favirapir is to disrupt the Corana virus from detaching the iron form the haema by competing with the same at the cell surface


3.  Chloroquine and hydroxycholoroquine

It works by blocking the aibility of the virus to enter into human cell and replicate.  (In our theory that it a blood disease, the medication competes with the virus from removing the iron from haeme.) The corona hairs from  reaching the ACE of the the cells  (see first picture)  Its efficacy was seen in anectdotal reports from France.   Pres Trump and Ellon Musk praised the drug to the heavens.  Its side effect, being toxic, however made some Euro countries dump the medication.  India banned the export of the drug, the country itself facing crisis with covid 19

4. Anti hypertensive drug.       Losartan it is an angiotensin receptor inhibitor and used mainly to reduce high blood pressure.  And works well when the covid 19 patient is hypertensive.   As an ACE inhibitor it may work to prevent the virus from attaching to the cell and multiplying.    Losartan is included in the protocol for treating coVid Patients (to lessen virus overload)   Persons whom we know of who were in Chinatown during Chinese New Year and who were on Losartan, and who developed the symptoms got better and were cured...

5.  Failed Ebola drug -  remdesivir. It is given to compassionate cases - ie those who are hopeless. However there has been a deluge of compassionate case and the said use is stopped.

6.  A combination HIV drug  Kaletra;  however the results of the trial was not conclusive, statistically significant.

7.  To counter auto immuno reaction  - cytokine reaction when the body overcome by infection goes into overdrive and attacks its own cells like in Lupus or arthritis. -  Actemra or tocolizumab. Mechanism of action it blocks cell receptor of Interlukine 6, a cytokine a protein that causes dangerous immune system reaction

The supportive treatment are Vitamin C, corticosteroid,  high flow oxygen,, and Zinc.

Maybe if we have zinc, we have people on Losartan, or safe ACE inhibitor we do not need the expensive vaccine they are developing (especially the the onebBill Gates Foundation is developing) as preventive  meds.  Those who are ill can be on Avigan.  

Is it now accepted that after preventing the findings of East Virginia, Dr. Sharif, that coVid19 is a cellular level oxygenation disease rather than a system respiratory disease?

For the former, we need more of hyperbaric chamber, blood transfusion, plasma pheresis (use of dialysis machine) and less of Ventilators and intubation.   Intubation is a dangerous procedure that infects the medical  practitioner and injures the patient...

N.B. The blogger  merely researches article and does not pretend to be a medical expert.   However, the articles are well referenced

Only Steroid and Pain killer - the Fabunan vaccine.

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Anti viral preparation by Dr. Ruben Fabunan of Zambales

Patent Application of Dr. Ruben Fabunan

Thought this was a new disruptive invention.


The much publicized invention of Dr  Ruben Fabunan from Zambales as cure for coVid19 was found to contain:


    1. Procaine (a pain killer)
    2. Dexamethasone (an anti flammatory - a steroid, a unversal cure for inflammation)

in the right formulation   A formulation

whose indication include virus caused diseases like flu, HIV, dengue. for full and speedy recovery.  And now our good doctor would like to treat coVid19  Sincerely I hope it works for all.  Sana all.

There is nothing new here because both components can readily be bought and available at all drugstores.  Surely the formulation would work vs co Vid because it is condition of inflammation - of free iron radicals disassociated from the haeme of the blood, causing inflammation of the lungs liver and other  vital organs.  Steroids, vit C, anti  LMWH anti coagulants, and steroid on top of high volume 02 are part of protocol for covid treatment.

The drug would surely mask the symptoms (inflammation and pain) but not the cause.... A vaccine would still have to be discovered.

Covid 19 Management Protocol from East Virginia posted at FB of Dr. Sharif Sultan

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                                      The new protocol does not support intubation.*

*Results in 100% fatality


It is an oxygenation failure, not a respiratory failure

The paper admonishes vs use of ventilators to prevent mechanical injury.  Let nature  heal the patient, according to their literature

Covid 19 Management Protocol

URGENT! Please circulate as widely as possible. It is crucial that every pulmonologist, every critical care doctor and nurse, every hospital administrator, every public health official receive this information immediately. This is our recommended approach to COVID-19 based on the best (and most recent) available literature including the Shanghai Management Guideline for COVID and recent information from Italy. We should not re-invent the wheel, but learn from the experience of others around the world. It is important to recognize that COVID-19 does not cause “typical ARDS”… this disease must be treated differently and it is likely that mechanical ventilation may be exacerbating this situation by causing ventilator induced lung injury (i.e. the ventilator may cause the disease we think we are treating). Patients suffer from oxygenation failure and not lung failure. Furthermore, this is predominantly an immune and clotting disorder and not a lung disease. This is a very dynamic situation; therefore, we will be updating the guideline as new information emerges. Please check on the EVMS website for updated versions of this protocol. EVMS COVID website: https://www.evms.edu/covid-19/medical_information_resources/ Short url: evms.edu/covidcare



https://www.evms.edu/media/evms_public/departments/internal_medicine/EVMS_Critical_Care_COVID-19_Protocol.pdf?fbclid=IwAR0Ra7gzMrBhtVk7W2GMZjNrdeCGajDByxkw6hSAg5OJo6wTXJpp-qBVw5Y


Intubation is not recommended


Prophylaxis While there is very limited data (and none specific for COVID-19), the following “cocktail” may have a role in the prevention/mitigation of COVID-19 disease. While there is no high level evidence that this cocktail is effective; it is cheap, safe and widely available. • Vitamin C 500 mg BID and Quercetin 250-500 mg BID • Zinc 75-100 mg/day (acetate, gluconate or picolinate). Zinc lozenges are preferred.


 After 1-2 months, reduce the dose to 30-50 mg/day. • Melatonin (slow release): Begin with 0.3mg and increase as tolerated to 1-2 mg at night • Vitamin D3 1000-4000 u/day (optimal dose unknown). Mildly Symptomatic patients (at home): • Vitamin C 500mg BID and Quercetin 250-500 mg BID (if available) • Zinc 75-100 mg/day • Melatonin 6-12 mg at night (the optimal dose is unknown) • Vitamin D3 1000-4000 u/day • Optional: Hydroxychloroquine 400mg BID day 1 followed by 200mg BID for 4 days


Mildly Symptomatic patients (on floor): • Vitamin C 500mg BID and Quercetin 250-500 mg BID (if available) • Zinc 75-100 mg/day • Melatonin 6-12 mg at night (the optimal dose is unknown) • Vitamin D3 1000-4000 u/day • Methylprednisolone 40 mg daily • Enoxaparin 40-60 mg daily • Optional: Hydroxychloroquine 400mg BID day 1 followed by 200mg BID for 4 days • N/C 2L /min if required (max 4 L/min; consider early t/f to ICU for escalation of care). • Avoid Nebulization and Respiratory treatments. Use “Spinhaler” or MDI and spacer if required. • Avoid non-invasive ventilation • T/f EARLY to the ICU for increasing respiratory signs/symptoms