Tuesday, May 1, 2012

Fwd: Health e-Tips - Treatment without evidence

Oh I thought this was our moringa  (malunggay)  If you can not afford the nutraceutical mentioned here,
go for, look for malunggay leaves or seeds in your backyard or that of your neighbor and be cured.

---------- Forwarded message ----------
From: Nutrition and Healing - Christine O'Brien <NutritionandHealing@newmarkethealth.com>
Date: Mon, Apr 30, 2012 at 10:11 PM
Subject: Health e-Tips - Treatment without evidence



Health e-Tips

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Dear Reader,

Trying to manage a child's autism is a daily struggle. An exhausted friend recently told me about the hours of research and discussion that led to an overhaul of her kitchen and, really, her life. To try to help her son, she's taken several foods off the family's menu. She's also been in constant contact with specialists and naturopathic doctors.

A couple of those specialists are more mainstream. They push antidepressants to treat the repetitive behaviors that come with her son's autism. They say there's research to back it up. But she didn't want to subject her son to SSRIs and other dangerous drugs. And it turns out her instincts were right.

You see, a new review of published and unpublished research about treating kids with autism with antidepressants reached an interesting conclusion. It turns out that incomplete information may be leading doctors to believe that these drugs can help treat autism symptoms.

That's right--all of these kids who are on SSRIs or similar drugs to treat their autism symptoms could be on drugs that are doing nothing. Well, nothing except exposing them to unnecessary risks, that is.

The study's lead author is calling for more research to see if the drugs really can help. I'm not sure what kind of magic she'll find in trying the drugs again--if they don't work, they don't work. And meanwhile they may be causing a lot of harm.

The review looked for trials that represent the gold standard of medical research: randomized, double-blind, placebo-controlled trials. The reviewers found a total of 15 trials. Five of those were thrown out because they didn't meet the researchers' standards. Another five had never even been published. When the researchers asked for the data from those unpublished trials, they received findings from only one. The authors of the other four ignored their requests.

Left with six trials, the researchers found that three showed some benefit and three showed that there was a small or no benefit. Overall, there was a small response to SSRIs, but when they accounted for the unpublished studies, the benefit disappeared.

Basically, the studies showing a positive reaction to SSRIs were the ones that were published. The ones that didn't find anything good to say about the drugs were, clearly, never supposed to see the light of day. When you suppress research like this it's called "publication bias."

The researchers said the benefits of SSRIs for autism have been "considerably overrated." They also fear that the incomplete and unpublished research means that doctors can't make informed decisions about SSRIs and autism. But that hasn't stopped countless pediatricians and specialists from prescribing them for kids.

Because of publication bias, the picture of SSRIs for autism looks rosier than it really is. And doctors are buying it. This is why it's crucial for all trial data to be made available. A trial shouldn't be swept under the rug just because it didn't turn out the way the researchers hoped.

We need to take a "warts and all" approach to drug data. Government research databases shouldn't be advertisements for pharmaceuticals. Yet, only 29 percent of completed clinical trials involving children have ever been published. And only 53 percent of studies funded through the NIH have been published.

So there's a big question: What's in those studies?

Basing prescriptions on an incomplete body of evidence is a dangerous game. Off-label drug use can't be advertised, but nothing stops a doctor from prescribing a drug for a condition for which it hasn't been approved. These decisions are being made based on incomplete and carefully selected data. Not on a full picture of what a given drug actually does and what risks are involved.

Publication bias is dangerous. And it's particularly awful when you're dealing with something as challenging and exhausting as managing a child's autism. We have to push for transparency and completeness when it comes to drug data. Otherwise, we're just shooting blind.

Yours in good health,

Christine O'Brien

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Sources:
"Evidence behind autism drugs may be biased: study," (Reuters reuters.com)



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